Epigenetic Profiling of H3K4Me3 Reveals Herbal Medicine Jinfukang-Induced Epigenetic Alteration Is Involved in Anti-Lung Cancer Activity

Table 3

GO analysis of top 2000 downregulated genes and upregulated genes, respectively.

Category	Item	Count	value
Downregulated
GO:0006811	Ion transport	112
GO:0016055	Wnt receptor signaling pathway	29
GO:0051347	Positive regulation of transferase activity	43
GO:0006350	Transcription	255
GO:0007242	Intracellular signaling cascade	162
GO:0051338	Regulation of transferase activity	59
GO:0033674	Positive regulation of kinase activity	41
GO:0043549	Regulation of kinase activity	57
GO:0045859	Regulation of protein kinase activity	55
GO:0045860	Positive regulation of protein kinase activity	39
Upregulated
GO:0012501	Programmed cell death	65
GO:0006917	Induction of apoptosis	39
GO:0050870	Positive regulation of T-cell activation	14
GO:0006915	Apoptosis	65
GO:0006631	Fatty acid metabolic process	27
GO:0012502	Induction of programmed cell death	39
GO:0031348	Negative regulation of defense response	9
GO:0052547	Regulation of peptidase activity	15
GO:0006793	Phosphorus metabolic process	97
GO:0006796	Phosphate metabolic process	97