Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo

Figure 1

Dihydromyricetin protected against cisplatin-induced general toxicity and nephrotoxicity in vivo. (a and b) BUN and SCr measurement. (c) Periodic acid-Schiff (PAS) staining. Kidney sections from the cisplatin-treated group showed severe cast formation and severe tubular injury. Cisplatin with DMY (500 mg/kg) showed less tubular destruction and mild casts (indicated with arrows). Data are presented as mean ± SD. versus cisplatin treatment group, versus cisplatin treatment group, and versus nondrug treatment group.

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