The Effects of Xiangqing Anodyne Spray on Treating Acute Soft-Tissue Injury Mainly Depend on Suppressing Activations of AKT and p38 Pathways

Figure 4

Representative histopathological micrographs (×200, HE staining) in the control (Ctrl), acute STI model (Mod), high-dose XQAS-treated (HXQAS), low-dose XQAS-treated (LXQAS), CPS-treated (CPS), and IHS-treated (IHS) group after modeling with or without repeated drug treatment for 8 h. Normal muscle tissue in Ctrl; severe muscle fibers disruption and necrosis, significant red blood cell accumulation in the interstitial space, and inflammatory cells infiltration in the Mod; very significant pathological improvement in injured muscle with markedly reduced area of the disruption and necrosis, decreased interstitial ecchymosed and inflammatory cells infiltration in the HXQAS group, and still marked muscle tissue injury but improved with marked muscle fibers disruption and necrosis, red blood cell accumulation in the interstitial space, and inflammatory cells infiltration in the LXQAS, CPS, and IHS group were shown.