Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms

Table 2

In vitro effects of isolated compounds against S. mansoni adult worms.

Groups	Incubation period (h)	Dead worms	Decrease of motor activity		Worms with tegumental alteration
			Slight	Significant		Slight
	24	0	0	0	0	0
	48	0	0	0	0	0
	72	0	0	0	0	0
0.5% DMSO	24	0	0	0	0	0
	48	0	0	0	0	0
	72	0	0	0	0	0
	24	100	0	100	0	100
	48	100	0	100	0	100
	72	100	0	100	0	100
Artemetin
100 µM	24	0	0	0	0	0
	48	0	0	0	0	0
	72	0	0	0	0	0
Hydroxypelenolide
100 µM	24	0	0	0	0	0
	48	0	0	0	0	0
	72	0	0	0	0	0
Santin
100 µM	24	0	0	0	0	0
	48	0	0	0	0	0
	72	0	0	0	0	0
Apigenin
100 µM	24	0	0	0	0	0
	48	0	0	0	0	0
	72	0	0	0	0	0
Parthenolide
100 µM	24	100	0	100	0	100
	48	100	0	100	0	100
	72	100	0	100	0	100
50 µM	24	100	0	100	0	100
	48	100	0	100	0	100
	72	100	0	100	0	100
25 µM	24	100	0	100	0	100
	48	100	0	100	0	100
	72	100	0	100	0	100
12.5 µM	24	0	0	0	0	0
	48	100	0	100	0	100
	72	100	0	100	0	100
6.25 µM	24	0	0	0	0	0
	48	0	0	0	0	0
	72	0	0	0	0	0

relative to 20 worms investigated.
1640.
at concentration of 5 µM.