Chinese Herbal Medicine as an Adjunctive Therapy Ameliorated the Incidence of Chronic Hepatitis in Patients with Breast Cancer: A Nationwide Population-Based Cohort Study
Table 2
Incidence rates, hazard ratio, and confidence intervals of chronic hepatitis for breast cancer patients with and without Chinses herb used in the stratification of sex, age, CCI score, and treatment.
Variables
Chinese herb used
Crude HR
Adjusted HR
No
Yes
( = 6928)
( = 6928)
Event
Person-years
IR†
Event
Person-years
IR†
(95% CI)
(95% CI)
Total
442
18931
23.35
441
29910
14.74
0.74 (0.64–0.84)
0.63 (0.54–0.72)
Age
18–39
66
3149
20.96
65
4955
13.12
0.69 (0.49–0.98)
0.65 (0.45–0.93)
40–59
351
14662
23.94
352
23198
15.17
0.75 (0.64–0.87)
0.63 (0.53–0.73)
≥60
25
1119
22.34
24
1757
13.66
0.71 (0.4–1.25)
0.64 (0.36–1.15)
CCI score
0
424
17983
23.58
424
28321
14.97
0.74 (0.65–0.85)
0.62 (0.54–0.72)
1
11
486
22.64
13
858
15.15
0.68 (0.3–1.57)
0.66 (0.28–1.54)
≥2
7
462
15.16
4
731
5.47
0.44 (0.13–1.5)
0.47 (0.13–1.69)
Treatment
Radiotherapy
No
263
9275
28.35
253
14587
17.34
0.72 (0.61–0.86)
0.58 (0.48–0.69)
Yes
179
9655
18.54
188
15323
12.27
0.75 (0.61–0.92)
0.7 (0.56–0.87)
Chemotherapy
No
89
3842
23.17
85
5780
14.71
0.74 (0.55–0.99)
0.68 (0.5–0.93)
Yes
353
15089
23.39
356
24130
14.75
0.73 (0.63–0.85)
0.61 (0.52–0.72)
Crude represented relative hazard ratio; adjusted represented adjusted hazard ratio: mutually adjusted for Chinese herb used, age, CCI score, treatment, and lag time in Cox proportional hazard regression. Lag time was defined as the duration between first diagnosis breast cancer dates and first accepted Chinese herb medicine date during the follow-up period. ,, and .
