Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3<i>β</i>/<i>β</i>-Catenin Signaling Pathway

<div>A hypothetical illustration for the role of CWP. PGE2, the main catalyzed product of Cox-2 from arachidonic acid, could bind to the EP receptor on the cell membrane, thereby activating the PI3K. Next, phosphorylation of AKT on Ser473 sites generated by PI3K and p-AKT can inhibit the activity of GSK3<i>β</i> by phosphorylating it. <i>β</i>-Catenin was accumulated in the cytoplasm and translocated into the nucleus, thereby activating downstream target genes MMPs.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 9

Figure 9: Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3<i>β</i>/<i>β</i>-Catenin Signaling Pathway 

Evidence-Based Complementary and Alternative Medicine

Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3β/β-Catenin Signaling Pathway

Figure 9