Platonia insignis Mart., a Brazilian Amazonian Plant: The Stem Barks Extract and Its Main Constituent Lupeol Exert Antileishmanial Effects Involving Macrophages Activation

Figure 6

Effect of EtOH-Ext, Hex-F, Lupeol, and the reference drug Amph B (2 μg/mL) on the infected macrophages (a) and the survival index of macrophage-internalized amastigotes (b) after 48 h of exposure. Murine peritoneal macrophages were infected with promastigote forms of L. amazonensis and then treated with concentrations related to respective IC₅₀, 1/2 IC₅₀, and 1/4 IC₅₀ against promastigotes. Results represent the means ± SEM of three experiments performed in triplicate. versus control.

(a)

(b)