Platonia insignis Mart., a Brazilian Amazonian Plant: The Stem Barks Extract and Its Main Constituent Lupeol Exert Antileishmanial Effects Involving Macrophages Activation

Table 1

Anti-Leishmania activity of EtOH-Ext, Hex-F, and Lupeol from P. insignis stem bark, and cytotoxic effects against murine peritoneal macrophages.

Compounds	Macrophages	Promastigotes	Axenic amastigotes
	CC50 (µg/mL)	CI50 (µg/mL)	CI50 (µg/mL)	SI
EtOH-Ext	341.95	174.24	40.58	8.42
Hex-F	71.65	45.23	35.87	1.99
Lupeol	144.00	39.06	44.10	3.26
Amph B	8.75	1.74	0.20	43.75

SI: Selectivity index for axenic amastigote forms of L. amazonensis (CC₅₀/IC₅₀).