Astragaloside IV Ameliorates Airway Inflammation in an Established Murine Model of Asthma by Inhibiting the mTORC1 Signaling Pathway

Figure 2

Airway responsiveness to aerosolized methacholine was evaluated by Buxco’s whole-body barometric plethysmography in awake, unrestrained mice. Group size: . The mice were nebulized with PBS followed by increasing doses (6.25 to 50 mg/mL) of methacholine. The enhanced pause (Penh) index of airway hyperreactivity was used as an indicator of changes in airway resistance. (a) The AHR was significantly increased after OVA reexposure compared to saline controls. Rapamycin (Rapa) (4 mg/kg/day) and dexamethasone (Dex) (1 mg/kg/day) suppressed the OVA-induced increases in the AHR after allergen reexposure. (b) AS-IV at 20 or 40.0 mg/kg had a remarkably inhibitory effect on the AHR. The data are expressed as the mean ± SEM. and versus OVA reexposure.

(a)

(b)