Astragaloside IV Ameliorates Airway Inflammation in an Established Murine Model of Asthma by Inhibiting the mTORC1 Signaling Pathway

Figure 5

Treg cell populations in BALF. (a) Representative graphs from each group were shown as follows: (A) saline; (B) OVA reexposure; (C) dexamethasone (Dex) (1 mg/kg/day); (D) rapamycin (Rapa) (4 mg/kg/day); (E) AS-IV 10 mg/kg group; (F) AS-IV 20 mg/kg; and (G) AS-IV 40.0 mg/kg group. (b) Foxp3⁺CD25⁺ cells, as a percentage of the total BALF CD4⁺ T cells, were reduced after the administration of Rapa and Dex. However, they were not reduced by AS-IV administration ( mice/group). (c) Total BALF regulatory T cells (Foxp3⁺CD25⁺) were increased after OVA reexposure and suppressed by Rapa and Dex, but they were not suppressed by AS-IV. ( mice/group). The data were expressed as the mean ± SEM. versus OVA reexposure.

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