Effects of Radix Astragali and Its Split Components on Gene Expression Profiles Related to Water Metabolism in Rats with the Dampness Stagnancy due to Spleen Deficiency Syndrome

Table 4

KEGG pathway enrichment analysis of DEGs.

Group	Term	Description	Count	value	Genes
G2 versus G1	KEGG:rno04080	Neuroactive ligand-receptor interaction	20		GPR83, CCKAR, TAAR7B, CCKBR, OPRL1, LEPR, OXTR, GRM1, CRHR2, ADRB1, NMUR1, GALR3, HTR6, GRM6, UTS2R, TAAR5, LHB, GLP1R, MTNR1A, HTR5B
	KEGG:rno04020	Calcium signaling pathway	12		CCKAR, SLC8A2, ADRB1, CCKBR, CALML3, HTR6, SPHK1, CACNA1G, OXTR, CAMK2A, GRM1, HTR5B
G3 versus G2	KEGG:rno04060	Cytokine-cytokine receptor interaction	11		VEGFB, IL1R2, CCL20, CXCL13, TNFRSF12A, IL18, CCR2, IL13, CSF3R, IL6R, TNFSF9
G4 versus G2	KEGG:rno04024	cAMP signaling pathway	17		ADCY3, VAV3, ADCY2, GRIN1, ATP1A3, CREB5, VAV2, ATP2B2, FOS, ATP2B3, SSTR2, CREB3L4, RAPGEF3, ADCY10, LIPE, GLP1R, AKT2
	KEGG:rno04020	Calcium signaling pathway	16		ADCY3, CCKAR, GNA15, ADCY2, TACR3, CCKBR, GRIN1, SPHK1, BDKRB1, NTSR1, ATP2B2, ATP2B3, PLCD4, CACNA1E, HTR2B, CACNA1A
	KEGG:rno04152	AMPK signaling pathway	11		SLC2A4, LEPR, SCD, PFKFB1, CREB3L4, CREB5, ADIPOQ, IRS1, LIPE, AKT2, PCK1
	KEGG:rno04080	Neuroactive ligand-receptor interaction	17		CCKAR, TAAR7B, TACR3, CCKBR, GRIK2, LEPR, GRIN1, PRSS1, BDKRB1, NTSR1, SSTR2, GALR1, LOC286960, PRSS3, HTR2B, GLP1R, GABRP
G5 versus G2	KEGG:rno03320	PPAR signaling pathway	10		CPT1B, APOA2, ACADM, PPARG, AQP7, GK, FABP2, ADIPOQ, SLC27A2, ACSL6
G6 versus G2	KEGG:rno04010	MAPK signaling pathway	40		IL1R2, IL1R1, FGF7, FGFR3, TNF, PDGFB, MAP4K2, CACNB1, FGF13, HSPA1B, CACNB4, TGFB2, KRAS, RAC2, SOS2, FAS, IL1A, HSPA8, AKT2, PRKCA, PTPN5, TAOK3, PTPRR, NR4A1, FGF20, MECOM, STK4, RPS6KA5, PLA2G4A, DUSP2, MAPK12, JUN, MAPK8, CACNA1E, MAPK8IP1, GADD45B, MAP3K14, GADD45A, DUSP8, CD14
	KEGG:rno04024	cAMP signaling pathway	28		PPARA, ADCY4, ADCY8, CNGB1, GRIN3A, SOX9, GLI3, ATP2B1, ATP2B2, ATP2B3, RAC2, CREB3L1, CREB3L4, CAMK2B, RAPGEF3, ADCY10, AKT2, PLD1, VAV3, ROCK2, ADCY9, JUN, ABCC4, GNAS, MAPK8, GHSR, GLP1R, LIPE
	KEGG:rno04151	PI3K-Akt signaling pathway	41		FGF7, PHLPP2, FGFR3, PDGFB, GNG13, KITLG, VTN, FGF13, BCL2L1, IGF1R, LAMB3, KRAS, COMP, ATF6B, TEK, SOS2, CREB3L1, GYS2, CREB3L4, THBS1, PPP2R2B, COL11A1, ANGPT2, AKT2, GHR, PRKCA, SGK1, SGK2, IL7, ITGA2, NR4A1, IL6R, FGF20, VEGFB, LAMA2, LAMA1, VEGFA, GNB5, LAMC2, LAMC1, INS1
G7 versus G2	KEGG:rno03320	PPAR signaling pathway	13		LPL, CYP4A1, CYP4A3, SCD, ADIPOQ, RGD1565355, PCK1, APOA2, CD36, LOC681458, APOC3, CYP4A8, FABP5
	KEGG:rno04020	Calcium signaling pathway	23		ORAI2, GNA15, CCKBR, ADCY8, TACR2, TACR1, SPHK1, BDKRB1, ATP2B2, P2RX7, CHRM5, PLCB3, ATP2B3, CAMK4, ADCY9, ATP2A3, P2RX2, TBXA2R, PLCD4, CHRNA7, HTR2B, PLCB2, CACNA1A
	KEGG:rno04152	AMPK signaling pathway	17		LEPR, SCD, IRS1, ADIPOQ, RGD1565355, PCK1, IGF1R, G6PC, EIF4EBP1, CD36, LOC681458, CREB3L1, GYS2, CREB3L4, PIK3R3, PPP2R2B, LIPE