Fuzheng Quxie Decoction Ameliorates Learning and Memory Impairment in SAMP8 Mice by Decreasing Tau Hyperphosphorylation

Figure 5

FQD inhibited tau protein hyperphosphorylation in SAMP8 mice. (a) Immunohistochemistry of t-Tau and p-Tau (S396) (×100). (b-c) Compared to the control group, the model group showed a significant increase in the MOD of CA1 region p-Tau (S396) . However, the MOD of t-Tau was not increased (). After treatment with memantine and FQD, the MOD of CA1 region p-Tau (S396) was significantly decreased ( and , resp.) compared to the untreated model group. The MOD of t-Tau was not statistically decreased (). (d) Western blot analyses, showing a significant increase in the level of p-Tau (S396) in model mice compared to control group . The expression of hippocampal p-Tau (S396) was significantly decreased after administration with memantine and high doses FQD . , .

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