Cryptotanshinone Regulates Androgen Synthesis through the ERK/c-Fos/CYP17 Pathway in Porcine Granulosa Cells

Figure 2

The androgen excess phenotype in porcine granulosa cells induced by PD98059 (values are mean ± SEM). (a) The testosterone level with 0 μM, 1 μM, 3 μM, 10 μM, and 25 μM PD98059 for 24 h. versus 0 μM (one-way ANOVA). (b) The testosterone level after culture times of 0 h, 1 h, 5 h, 24 h, 48 h, and 72 h with 10 μM PD98059. versus 0 h (one-way ANOVA). All experiments were repeated at least three times.

(a)

(b)