Spatholobus suberectus Exhibits Antidiabetic Activity In Vitro and In Vivo through Activation of AKT-AMPK Pathway

Figure 4

In vivo antidiabetic activity of Spatholobus suberectus. STZ-induced diabetic mice were treated with EeSs or acarbose at 200 mg/kg dose and oral glucose tolerance test was monitored at various time intervals (a) after an oral load of glucose (2 gm/kg). After treatment, the skeletal muscle tissues were excised and RT-PCR analysis (b) was performed, followed by western blot analysis (c and d). NT: not treated; SDC: STZ-induced diabetic control mice; SDAC: STZ-induced diabetic acarbose-treated mice; SDEeSs: STZ-induced diabetic EeSs-treated mice. versus NT; versus SDC group using ANOVA followed by LSD test.

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