Schisandra chinensis and Morus alba Synergistically Inhibit In Vivo Thrombus Formation and Platelet Aggregation by Impairing the Glycoprotein VI Pathway

Figure 1

In vivo effects of the SCC + MAL mixture on thrombus formation. (a) The arteriovenous (AV) shunt model was used to evaluate in vivo antithrombotic activity. Rats received SCC, MAL, or SCC + MAL extracts or vehicle, orally once a day for 3 days. On the 3rd day, 2 h after oral administration, blood circulation in the cannula carried out for 15 min, and thrombus weight determined immediately. (b) Rat tail thrombosis-length model was used to evaluate inhibitory effects on tail thrombosis. Rats received SCC, MAL, or SCC + MAL extracts, ASA, or vehicle, orally once a day for 7 days. On the 4th day, 30 min after oral administration, rats were injected with a single dose of κ-carrageenan (20 mg/kg BW i.p.) dissolved in physiological saline. Bar graph shows the mean ± SEM for AV shunt ( = 3 rats in each group) and tail thrombosis ( rats in each group). ,  , and versus control.

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