Danggui Buxue Extract-Loaded Liposomes in Thermosensitive Gel Enhance In Vivo Dermal Wound Healing via Activation of the VEGF/PI3K/Akt and TGF-β/Smads Signaling Pathway

Figure 4

Immunohistochemical staining for CD34 (a), Ki67 (b), Col1α1 (c), and Col3α1 (d) in rat wound granulation tissue at each time point following surgery in the three treatment groups ( = 3). (A) Immunohistochemical images and (B) immunohistochemical analysis results are shown. < 0.01 versus model control; < 0.001 versus model control; < 0.05 versus vehicle control; < 0.01 versus vehicle control; < 0.001 versus vehicle control. IOD, integrated optical density; DBLTG, Danggui Buxue extract- (DBE-) loaded liposomes in thermosensitive gel.

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