Evaluation of Analgesic Activity of Papaver libanoticum Extract in Mice: Involvement of Opioids Receptors

Table 1

Analgesic effect of different doses of PLE by tail flick method in mice.

Treatment	Reaction time (sec, mean ± SEM)
	0 hrs	0.5 hrs	1 hr	1.5 hrs	2 hrs	3 hrs	4 hrs	6 hrs	8 hrs	24 hrs
Control (vehicle)	2.78 ± 0.13	2.82 ± 0.18	2.8 ± 0.14	2.86 ± 0.23	2.92 ± 0.2	2.88 ± 0.04	2.90 ± 0.28	2.82 ± 0.23	3 ± 0.28	2.9 ± 0.25
PLE 12.5 mg/kg	2.76 ± 0.05	2.9 ± 0.1	2.87 ± 0.15	2.8 ± 0.26	2.8 ± 0.1	2.8 ± 0.36	2.9 ± 0.36	2.73 ± 0.15	2.83 ± 0.25	2.8 ± 0.2
PLE 25 mg/kg	2.57 ± 0.24	2.8 ± 0.23	3.33 ± 0.72	3.28 ± 0.5	3.58 ± 0.78	3.7 ± 0.64	3.42 ± 0.54	2.8 ± 0.27	2.95 ± 0.21	2.85 ± 0.07
PLE 50 mg/kg	3.14 ± 0.11	3.24 ± 0.11	3.88 ± 0.8	4.76 ± 0.73	4.8 ± 1.15	5.24 ± 1.3	4.76 ± 1.13	3.68 ± 0.97	3.4 ± 0.14	2.85 ± 0.07
PLE 75 mg/kg	2.93 ± 0.42	3 ± 0.6	4 ± 0.7	5.27 ± 1.32	6.03 ± 1.19	6.5 ± 0.95	5.93 ± 0.95	4.77 ± 1.16	3.95 ± 0.49	3.05 ± 0.21
PLE 100 mg/kg	2.87 ± 0.17	3.51 ± 0.24	4.20 ± 0.76	5.84 ± 0.66	7.09 ± 0.8	7.46 ± 0.82	6.44 ± 0.83	5.63 ± 0.67	5.15 ± 0.78	4 ± 0.14
PLE 150 mg/kg	2.65 ± 0.13	3.63 ± 0.43	4.68 ± 0.57	6.15 ± 0.9	7.23 ± 0.61	8.25 ± 0.99	7.53 ± 0.75	6.15 ± 0.6	5.7 ± 0.1	4.67 ± 0.25
PLE 200 mg/kg	2.89 ± 0.17	4.47 ± 0.44	4.84 ± 0.47	6.79 ± 0.63	7.81 ± 0.55	10.07 ± 1.32	8.1 ± 1.07	6.8 ± 1.26	6.25 ± 0.78	5.05 ± 0.21
Morphine (5 mg/kg)	2.81 ± 0.18	11.31 ± 1.92	9.30 ± 1.36	7.61 ± 0.73	6.23 ± 0.47	4.16 ± 0.79	3.77 ± 0.46	3.44 ± 0.39	3.15 ± 0.21	3 ± 0.14

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