Pharmacokinetics of Caffeic Acid, Ferulic Acid, Formononetin, Cryptotanshinone, and Tanshinone IIA after Oral Administration of Naoxintong Capsule in Rat by HPLC-MS/MS

Table 6

Pharmacokinetic parameters of five compounds in rat plasma after oral administration of single dose and triple dose of NXT capsule. (, mean ± SD).

Analytes	Caffeic acid		Ferulic acid		Formononetin		Cryptotanshinone		Tanshinone IIA
	0.5 g kg^−1	1.5 g kg^−1	0.5 g kg^−1	1.5 g kg^−1	0.5 g kg^−1	1.5 g kg^−1	0.5 g kg^−1	1.5 g kg^−1	0.5 g kg^−1	1.5 g kg^−1
(h)	0.18 ± 0.03	0.20 ± 0.04	0.17 ± 0.00	0.19 ± 0.04	0.49 ± 0.33	0.38 ± 0.25	0.51 ± 0.40	0.60 ± 0.20	0.54 ± 0.29	3.17 ± 3.75
(ng/mL)	9.80 ± 4.40	15.24 ± 3.08	10.93 ± 4.67	12.07 ± 4.61	0.11 ± 0.05	0.37 ± 0.32	0.61 ± 0.23	2.78 ± 2.52	1.61 ± 1.11	4.18 ± 3.34
(h)	0.83 ± 0.33	0.70 ± 0.35	0.20 ± 0.19	0.42 ± 0.15	2.96 ± 5.61	1.42 ± 0.69	2.93 ± 3.89	17.8 ± 17.1	11.4 ± 15.8	13.2 ± 10.4
(ng/mLh)	11.68 ± 9.60	25.99 ± 18.62	3.20 ± 1.55	8.33 ± 3.87	0.08 ± 0.05	1.47 ± 1.82	1.49 ± 0.76	24.8 ± 27.9	8.15 ± 4.85	35.4 ± 42.2
(ng/mLh)	19.57 ± 21.12	28.52 ± 20.01	4.19 ± 2.30	14.4 ± 12.8	0.15 ± 0.09	3.06 ± 3.07	4.72 ± 5.99	55.2 ± 59.8	27.7 ± 36.2	83.0 ± 81.0
(h)	1.33 ± 1.19	2.03 ± 1.43	0.28 ± 0.10	0.81 ± 0.38	0.56 ± 0.23	5.16 ± 3.68	3.06 ± 1.47	7.37 ± 3.95	5.48 ± 1.66	5.75 ± 3.36
(h)	4.02 ± 4.96	2.72 ± 1.82	0.48 ± 0.33	3.80 ± 6.11	1.67 ± 1.53	25.9 ± 31.8	20.7 ± 27.7	19.0 ± 17.5	26.8 ± 31.5	27.2 ± 20.6