Hepatotoxicity in Rats Induced by Aqueous Extract of Polygoni Multiflori Radix, Root of Polygonum multiflorum Related to the Activity Inhibition of CYP1A2 or CYP2E1

Figure 5

Typical histopathological section photographs of rat hepatic light microscopic changes after administration of PMR and inhibitor of CYP1A2 or CYP2E1. Sections of rat livers from all groups were stained with HE and examined under light microscope (Olympus BX51). (a) Control group; (b) PMR group; (c) CYP1A2 inhibitor control group; (d) CYP2E1 inhibitor control group; (e) CYP1A2 inhibitor and PMR group; (f) CYP2E1 inhibitor and PMR group. The enlarged panels in (e) and (f) indicate the details of pathologic changes.

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