Clinical Efficacy and Safety of Benjakul Remedy Extract for Treating Primary Osteoarthritis of Knee Compared with Diclofenac: Double Blind, Randomized Controlled Trial
Table 7
Blood pressure, renal functions, and liver functions in safety issue.
Follow-up
Treatments
BJK recipe
Diclofenac
Blood pressure
Systolic blood pressure (normal ≤ 140 mm⋅Hg)
Day 0
126.6 (12.82)
126.26 (17.24)
Day 14
126.25 (15.24)
128.05 (15.28)
Day 28
122.64 (12.41)
125.22 (14.59)
Diastolic blood pressure (normal ≤ 90 mm⋅Hg)
Day 0
81.90 (9.23)
78.31 (8.5)
Day 14
79.8 (9.07)
81.95 (12.43)
Day 28
80.26 (8.43)
80.61 (10.97)
Renal functions
Blood urea nitrogen; BUN (mg/dL) (ref.range = 7.0–18.0)
Day 0
13.24 (3.7)
13.3 (3.4)
Day 14
13.05 (3.98)
14.84
Day 28
12.9 (3.29)
15.38
Creatinine (mg/dL) (ref.range = 0.7–1.3)
Day 0
0.71 (0.19)
0.7 (0.17)
Day 14
0.73 (0.18)
0.73 (0.17)
Day 28
0.69 (0.17)
0.73
Liver functions
AST (U/L) (ref.range = 15–37)
Day 0
23.6 (10.68)
23.12 (8.27)
Day 14
25.28 (11.34)
28.1
Day 28
25.03 (11.8)
26.6
ALT (U/L) (ref.range = 30–65)
Day 0
39.6 (12.2)
40.69 (15.1)
Day 14
39.65 (14.36)
45.77
Day 28
40.33 (14.6)
44.92
ALP (U/L) (ref.range = 50–136)
Day 0
90.45 (18.19)
90.38 (22.6)
Day 14
90.95 (18.84)
97.38 (24.52)
Day 28
91.49 (19.51)
100.82
represent mean (SD), analysis: two-sample Student’s -test, test. For all within group statistical analysis: Repeated Measure ANOVA. difference from day 0 within group ( value < 0.05), difference from day 0 within group ( value ≤ 0.01), and difference from day 0 within group ( value ≤ 0.001).
