Review Article

Evaluation of Efficacy and Safety of Dan’e-Fukang Soft Extract in the Treatment of Endometriosis: A Meta-Analysis of 39 Randomized Controlled Trials Enrolling 5442 Patients

Table 1

Characteristics of enrolling randomized controlled trials.

IDSample size (I/C)Age (I/C)SurgeryIntervention methodsControlled methodsTreatment courseFollowing upOutcomes

Bi and Wang 201323/19UnreportedN/ADan’e-fukang, 10 g each time, 2 times a day, taken 14 days before menstruationMifepristone, 12.5 ng each time, 2 times a day3 monthsN/ADysmenorrhea, safety
Cai et al. 2004343/16035 (16–48)N/ADan’e-fukang, 10 g each time, 2 times a day, taken 15 days before menstruationDanazol, 200 mg each time, 3 times a day3 monthsN/AEffective rate
Chen WZ 201062/58I: 35.0 ± 3.3; C: 34.0 ± 3.1PostoperationDan’e-fukang, 10 g, 1 time a day; Diphereline 3.75 mg intramuscular injection, 28 days once, 3 times totally Diphereline, 3.75 mg intramuscular injection, 28 days once, 6 times totally6 months12 monthsEffective rate, rate of pregnancy, recurrence rate, safety
Chen 200940/38I: 30.4 ± 10.0; C: 33.4 ± 8.7PostoperationDan’e-fukang, 10 g each time, 3 times a dayGestrinone, 2.5 mg each time, 2 times a week6 months18 months Rate of pregnancy, recurrence rate, safety
X. H. Chen and X. L. Chen 201055/55I: 36.88 ± 5.96; C: 34.13 ± 7.25N/ADan’e-fukang, 15 g each time, 2 times a day, taken 10 days before menstruation, keep taken in menstrual periodGestrinone, 2.5 mg each time, 2 times a week3 monthsN/AEffective rate, dysmenorrhea, safety
Chen 201160/60I: 34 (21–45); C: 31 (19–46)N/ADan’e-fukang, 15 g each time, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week6 monthsN/AEffective rate, safety
Di and Lou 200731/29UnreportedN/ADan’e-fukang, 10 g each time, 2 times a day, taken 10 days before menstruationMifepristone, 12.5 mg each time, 2 times a day3 monthsN/AEffective rate, safety
Huang 201264/64I: 29.15 ± 4.65; C: 28.95 ± 4.85N/ADan’e-fukang, 10 g each time, 2 times a dayDanazol, 200 mg, Mifepristone, 12.5 mg each time, 3 times a day2 monthsN/AEffective rate, CA125, safety
Huang et al. 201338/38I: 37.4 ± 4.5; C: 34.5 ± 5.1PostoperationDan’e-fukang, 15 g each time, 2 times a day; Mifepristone, 10 mg/d, 1 time a dayMifepristone, 10 mg, 1 time a day3 monthsN/AEffective rate, recurrence rate, safety
Jin et al. 201160/60I: 34 (21–45); C: 31 (19–46)N/ADan’e-fukang, 15 g each time, 2 times a day, taken 15 days before menstruationGestrinone, 2.5 mg each time, 2 times a week6 monthsN/AEffective rate, safety
Jin et al. 201356/56I: 32.6 ± 4.7; C: 31.2 ± 4.3N/ADan’e-fukang, 15 g each time, 2 times a day, taken 10 days before menstruationDanazol, 200 mg each time, 3 times a day3 monthsN/AEffective rate, safety
Li and Zhu 201045/4518–44N/ADan’e-fukang, 15 g each time, 2 times a day, taken 10 days before menstruationMifepristone, 12.5 mg each time6 monthsN/AEffective rate
45/45Dan’e-fukang, 15 g each time, 2 times a day, taken 10 days before menstruationMarvelon, 2.5 mg, 1 time a day
Li 201247/4736.6 (22–48)PostoperationDan’e-fukang, 10 g each time, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week6 monthsN/AEffective rate, recurrence rate, safety
Lin and Fu 200672/58I: 33.8 ± 7.3; C: 34.8 ± 6.1N/ADan’e-fukang, 15 g each time, 2 times a day, taken 10 days before menstruationGestrinone, 2.5 mg each time, 2 times a week6 months1 year–3 yearsEffective rate, CA125, rate of pregnancy, symptom score, safety
Shen et al. 201128/2819–42N/ADan’e-fukang, 10–15 g each time, 2 times a day; Mifepristone, 6.25 mg, 1 time a dayMifepristone, 10 mg, 1 time a day3 months3 monthsDysmenorrhea, safety
Shen and Wang 201396/97I: 37.0 ± 6.3; C: 36.7 ± 5.8N/ADan’e-fukang, 10 g each time, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week6 monthsN/AEffective rate, CA125, safety
Tu 2011343/16035 (16–48)N/ADan’e-fukang, 10 g each time, 2 times a day, taken 15 days before menstruationDanazol, 200 mg, 3 times a day3 monthsN/AEffective rate, safety
>Wang et al. 2013200/200UnreportedN/ADan’e-fukang, 10–15 g each time, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week3 months1 yearDysmenorrhea, recurrence rate, safety
Wang 200840/40I: 28.15 (19–45); C: 30 (21–43)N/ADan’e-fukang, 10 g each time, 2 times a day,Gestrinone, 2.5 mg each time, 2 times a week3 monthsN/AEffective rate, safety
Wang and Hu 200730/30I: 30 ± 3.5; C: 29 ± 4.4PostoperationDan’e-fukang, 15 g each time, 2 times a dayNo treatment2 months12 monthsEffective rate, rate of pregnancy, recurrence rate, safety
Wu et al. 200480/42I: 32 (23–41); C: 32.5 (24–40)N/ADan’e-fukang, 10–15 g each time, 2 times a dayMarvelon, taken on the fifth day of menstruation, 1 tablet a day3 monthsN/AEffective rate, improvement of symptoms
Xiong et al. 201430/30I: 27.3 ± 1.9; C: 29.1 ± 2.7PostoperationDan’e-fukang, 10 g each time, 2 times a dayDanazol, 200 g each time, 3 times a day6 months6 monthsEffective rate, recurrence rate, safety
Xiong and Wang 201265/55I: 34.3, C: 33.8N/ADan’e-fukang, 15 g each time, taken 10 days before menstruation, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week3 months3 monthsEffective rate, CA125, rate of pregnancy, safety
Xu 201187/71I: 36.21 ± 5.25; C: 36.96 ± 5.31N/ADan’e-fukang, 15 g each time, taken 10 days before menstruation, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week3 months3 monthsEffective rate, dysmenorrhea, CA125, rate of pregnancy, safety
Xu et al. 201372/7225–49N/ADan’e-fukang, 15 g each time, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week3 monthsN/AEffective rate, dysmenorrhea, safety
Yang 201591/92I: 37.01 ± 6.3; C: 36.7 ± 5.8N/ADan’e-fukang, 10 g each timeGestrinone, 2.5 mg each time, 2 times a week6 monthsN/AEffective rate, CA125, rate of pregnancy, safety
Yang et al. 201037/34UnreportedPostoperationDan’e-fukang, 10 g each time, 2 times a dayMifepristone, 10 mg each time, 1 time a day6 monthsN/AEffective rate, rate of pregnancy, recurrence rate, safety
Yao 200560/60I: 28.5 (23–40); C: 30 (21–43)N/ADan’e-fukang, 10 g each time, 2 times a day, taken 10 days before menstruationGestrinone, 2.5 mg each time6 monthsN/AEffective rate, safety
Yao et al. 201360/6036 (18–50)N/ADan’e-fukang, 15 g each time, 2 times a day, taken 15 days before menstruationDanazol, 200 mg each time, 3 times a day3 monthsN/AEffective rate
Yin et al. 201460/60I: 34.9 ± 7.1; C: 35.9 ± 5.9N/ADan’e-fukang, 10 g each time, 2 times a dayIntrauterine placed Mirena9 monthsN/AEffective rate
Zhang et al. 201060/3033.4 (20–53) N/ADan’e-fukang, 10–15 g each time, 2 times a day, taken 10 days before menstruationGestrinone, 2.5 mg each time, 2 times a week;3 monthsN/ADysmenorrhea, safety
60/20Dan’e-fukang, 10–15 g each time, 2 times a day, taken 10 days before menstruationPlacebo
Zhang and Li 200853/5036 (18–50)N/ADan’e-fukang, 10 g each time, 2 times a dayDanazol, 200 mg each time, 3 times a day3 monthsN/AEffective rate, safety
Zhang and Li 200740/35I: 33.0 ± 2.7; C: 34.0 ± 5.4PostoperationDan’e-fukang, 10 g each time, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week3 monthsN/AEffective rate, rate of pregnancy, safety
Zhang and Ren 2008112/4334.6 (19–48)N/ADan’e-fukang, 15 g each time, 2 times a day,Danazol, 200 mg each time, 2 times a day3 months3 monthsEffective rate
Zhao 201375/75I: 35.9 ± 5.68; C: 36.7 ± 6.8PostoperationDan’e-fukang, 10 g each time, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week7 monthsN/AEffective rate, recurrence rate, safety
Zhao et al. 201118/2021–42PostoperationDan’e-fukang, 15 g each time, 2 times a day, taken 10 days before menstruationGestrinone, 2.5 mg each time, 2 times a week6 months1 yearEffective rate, hormone level
X. H. Zheng and J. B. Zheng 2015105/105I: 36.25 ± 4.35; C: 36.05 ± 4.01N/ADan’e-fukang, 15 g each time, 2 times a dayGestrinone, 2.5 mg/d, the first taken on the first day of menstruation, the second taken on the fourth day of menstruation3 monthsN/AEffective rate, dysmenorrhea, CA125, rate of pregnancy, safety
Zhu 201050/41I: 36.19 ± 4.66; C: 37.34 ± 4.98N/ADan’e-fukang, 15 g each time, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week3 months3 monthsDysmenorrhea, safety
Zhu 201332/3235.8 ± 2.3N/ADan’e-fukang, 10 g each time, 2 times a dayGestrinone, 2.5 mg each time, 2 times a week6 monthsN/AEffective rate, CA125, safety
Zhu and Lei 201050/5036.19 ± 4.84PostoperationDan’e-fukang, 10 g each time, 2 times a day, taken 1 week after operationGestrinone, 2.5 mg each time, 2 times a week, taken 1 week after operation6 months3 yearsEffective rate, dysmenorrhea, recurrence rate, improvement of symptoms