Antiobesity Effect of Astilbe chinensis Franch. et Savet. Extract through Regulation of Adipogenesis and AMP-Activated Protein Kinase Pathways in 3T3-L1 Adipocyte and High-Fat Diet-Induced C57BL/6N Obese Mice

Table 3

Effects of Astilbe chinensis Franch.et Savat. extract on body weight and biomarkers in mice fed a high-fat diet.

Groups	RD	HFD	AC 100	AC 200
Initial body weight (g)	21.2 ± 1.	21.7 ± 1.	21.8 ± 1.	21.7 ± 1.
Final body weight (g)	29.8 ± 2.	43.5 ± 2.	31.8 ± 1.	30.2 ± 2.
Body weight gain (g)	8.5 ± 1.	21.6 ± 1.	9.8 ± 1.	8.4 ± 1.
Food intake (g/day)	3.13 ± 0.	3.26 ± 0.	3.31 ± 0.	3.28 ± 0.
Feed efficiency	0.72 ± 0.	3.66 ± 0.	1.79 ± 0.	1.33 ± 0.
Plasma glucose (mM)	5.3 ± 0.	8.6 ± 0.	6.1 ± 1.	6.0 ± 0.
Plasma insulin (μU/mL)	60.1 ± 6.	163.6 ± 1	87.3 ± 7.	74.3 ± 1
TG (mg/mL)	48.7 ± 6.	88.3 ± 9	42.3 ± 7.	68.5 ± 2
TC (mg/mL)	50.8 ± 4.	116.1 ± 5	58.4 ± 6.	51.1 ± 1
LDL-cholesterol (mg/mL)	13.3 ± 2.	32.3 ± 3	21.1 ± 1.	19.3 ± 2

Results are presented as mean ± SEM (n = 8). Values within a row with different letters are significantly different from each other (p< 0.05). RD: regular diet group; HFD, high-fat diet group; AC 100, HFD + Astilbe chinensis Franch. et Savat. (AC) extract 100 mg/kg treatment; AC 200, HFD + Astilbe chinensis Franch. et Savat. (AC) extract 200 mg/kg treatment; TG: triacylglycerol; TC: total cholesterol; LDL: low-density lipoprotein; : not significant.