Effects of Qi-Fang-Xi-Bi-Granules on Cartilage Morphology and C/ebpα Promoter Methylation in Rats with Knee Osteoarthritis

Figure 6

C/ebpα methylation at various sites. N stands for normal control group, KOA stands for KOA model group, C stands for Celebrex group, V stands For Viartril-S group, L stands for low-dose QFXBG group, M stands for medium-dose QFXBG group, H stands for high-dose QFXBG group, and T stands for the combination of L M and H Groups; (a) C/ebpα-22 with the CpG islands 1881 bp to the initiation codon; (b) C/ebpα-2 with the CpG islands −458 bp to the initiation codon; (c) C/ebpα-2 with the CpG islands −452 bp to the initiation codon; (d) differences in methylation rates among groups QFXBGs and KOA model group. , , and versus N group; and versus KOA group.

(a)

(b)

(c)

(d)