A Network Pharmacology Approach to Uncover the Potential Mechanism of Yinchensini Decoction

Table 2

Important node of YCSND compound-target network.

Node Name	Node Type	Degree	Betweenness Centrality
Quercetin	Compound	154	0.51220399
Prostaglandin G/H synthase 2	Target	98	0.09990361
Estrogen receptor	Target	80	0.03095638
Calmodulin	Target	77	0.01919701
Heat shock protein HSP 90	Target	74	0.06433216
Nitric oxide synthase, inducible	Target	74	0.01539794
Androgen receptor	Target	73	0.03326497
Kaempferol	Compound	63	0.10360504
Trypsin-1	Target	63	0.02571407
Cell division protein kinase 2	Target	62	0.00804666
Glycogen synthase kinase-3 beta	Target	61	0.0087541
Peroxisome proliferator-activated receptor gamma	Target	61	0.02602051
Proto-oncogene serine/threonine-protein kinase Pim-1	Target	61	0.00731391
Estrogen receptor beta	Target	60	0.00760087
Coagulation factor Xa	Target	55	0.01878226
Cyclin-A2	Target	53	0.00546001
Nuclear receptor coactivator 2	Target	52	0.05181668
Prostaglandin G/H synthase 1	Target	52	0.04921123
Sodium channel protein type 5 subunit alpha	Target	51	0.02323399
Dipeptidyl peptidase IV	Target	45	0.02031966
7-Methoxy-2-methyl isoflavone	Compound	43	0.0274993
Formononetin	Compound	39	0.0438877
beta-sitosterol	Compound	38	0.06644929
Thrombin	Target	38	0.01452236
Isorhamnetin	Compound	37	0.03169965
Naringenin	Compound	37	0.1201062
Medicarpin	Compound	34	0.02391904
mRNA of PKA Catalytic Subunit C-alpha	Target	34	0.03269624
licochalcone a	Compound	32	0.02913105
2-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]-5-methoxyphenol	Compound	31	0.00718614
Beta-2 adrenergic receptor	Target	31	0.01440293
DNA topoisomerase II	Target	31	0.00830063
shinpterocarpin	Compound	30	0.01309466
Vestitol	Compound	30	0.00877921
Licoagrocarpin	Compound	29	0.00658159
Retinoic acid receptor RXR-alpha	Target	28	0.01008831
Glypallichalcone	Compound	27	0.00712433
Glyasperins M	Compound	26	0.00616704
Acetylcholinesterase	Target	24	0.00976155
Coagulation factor VII	Target	22	0.00700284
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform	Target	17	0.01365074
Potassium voltage-gated channel subfamily H member 2	Target	16	0.00643202
Nitric-oxide synthase, endothelial	Target	14	0.00565094
Demethoxycapillarisin	Compound	13	0.01972483