Toll-Like Receptor 4–Myeloid Differentiation Primary Response Gene 88 Pathway Is Involved in the Shikonin Treatment of CIA by Regulating Treg/Th17 Expression

Table 2

Histology of knee joints after shikonin treatment (, n=5).

Group	Infiltrate	Cartilage destruction	Bone erosion
Control	1.20±0.5	1.10±0.30	1.90±0.70
Shikonin-high	0.71±0.4	0.19±0.28	0.57±0.37
Shikonin- medium	0.83±0.4	0.31±0.28	0.78±0.43
Shikonin-low	1.10±0.5	0.79±0.40	1.13±0.53
Celecoxib	0.80±0.5	0.93±0.40	1.72±0.36

Note: ^∗P <0.05, ^∗∗P <0.01 versus controls.