SYKT Alleviates Doxorubicin-Induced Cardiotoxicity via Modulating ROS-Mediated p53 and MAPK Signal Pathways

<div>Influence of DOX on cytoplasmic and mitochondrial Bax and cytochrome c expression is time-dependent. Mouse primary cardiomyocytes were treated with 1 <i>μ</i>M DOX for 1-8 h. Over time, cytoplasmic Bax expression gradually decreased and cytochrome c expression gradually increased, whereas mitochondrial Bax expression gradually increased and cytochrome c expression gradually decreased. <i>β</i>-Actin was used as the internal control, and Prohibitin was used as a mitochondrial marker.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4: SYKT Alleviates Doxorubicin-Induced Cardiotoxicity via Modulating ROS-Mediated p53 and MAPK Signal Pathways 