Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach

Figure 1

Identification of a core PPI network for baicalin against ischemic stroke. (a) Construction of two PPI networks of baicalin targets and ischemic stroke targets. (b) The interactive PPI network of baicalin and ischemic stroke targets comprising 4809 nodes and 132441 edges is shown. (c) PPI network of significant proteins extracted from (b); this network comprises 1139 nodes and 51966 edges. (d) PPI network of significant proteins extracted from (c); this network is made up of 386 nodes and 16825 edges. BC: betweenness centrality; CC: closeness centrality; DC: degree centrality; EC: eigenvector centrality; NC: network centrality; LAC: local average connectivity.