Gastroprotective Mechanism and Ulcer Resolution Effect of Cyrtocarpa procera Methanolic Extract on Ethanol-Induced Gastric Injury

Figure 1

CpMet gastroprotective mechanism in an ethanol-induced gastric ulcer model in mice. (a) Protocol validation and (b) effect of CpMet. CpMet, C. procera methanolic extract 100 mg/kg; VEH, isotonic saline solution; L-NAME, N^ω-nitro-L-arginine methyl ester 10 mg/kg; INDO, indomethacin 10 mg/kg; NEM, N-ethylmaleimide 1 mg/kg; GLIB, glibenclamide 5 mg/kg. Each column represents the mean ± SEM of three independent replicates ( per group). An ANOVA was performed followed by Tukey’s test. For (a), , significant difference versus control (VEH); NS, no significant difference between the four pretreatments. For (b), , significant difference (VEH + CpMet + ETOH) versus control (VEH + VEH + ETOH); , , significant difference between (pretreatment + CpMet + ETOH) versus control (VEH + CpMet + ETOH).