Gastroprotective Mechanism and Ulcer Resolution Effect of Cyrtocarpa procera Methanolic Extract on Ethanol-Induced Gastric Injury

Figure 6

Positive control. Mice stomach treated with CAR (50 mg/kg, twice a day) on the 20th day after GU induction. (a) Macroscopic view of a formalin fixed stomach showing only some minor scars (dashed box). (b), (c), and (d) Bright-field microscopic views of 5 μm thickness sagittal sections of the glandular portion of the stomach, stained with PAS. (b) Panoramic histopathological appearance showing robust basal architecture with some alterations at the apical portion of the mucosa and abundant clusters of PAS-positive staining regions. Dashed boxes: right, magnification to show mucus presence; left, histopathological status of the tissue. (c) Gastric mucosa revealing normal glandular organization without inflammatory infiltrate. (d) Gastric mucosa with strong PAS positivity surrounding the epithelia and areas of expanded surface mucous cells. In some areas, a slightly disrupted regeneration of the gastric epithelium is observed.