Holistic Regulation of Angiogenesis with Chinese Herbal Medicines as a New Option for Coronary Artery Disease

Figure 1

Schematic representation of major targets of angiogenesis. Nox4: nicotinamide adenine dinucleotide phosphate oxidase 4, HIF-1α: hypoxia-inducible factor-1α, CRP: C-reactive protein, TNF-α: tumor necrosis factor-α, VCAM-1: vascular cell adhesion molecule-1, MMPs: matrix metalloproteinases, Dll4: delta-like ligand 4, SHC: synthesized hydrocarbon, PKC: protein kinase C, PLC-γ: phospholipase C-γ, IP3: inositol triphosphate 3, and NOS: nitric oxide synthase.