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| Study ID | Objects | Chinese herbs and formulae | Study design | Composition of formula | Therapeutic effect and mechanism |
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| Chen et al. [29] | 8 rats | Xiongshao capsule | Gavage for 6 weeks | Ligusticum chuanxiong Hort., Radix paeoniae rubra | Increase the expression levels of VEGF and bFGF, promote angiogenesis, enhance myocardial blood supply, improve cardiac function |
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| Zeng et al. [30] | 10 rats | Guanxin No. 2 | Gavage with 20 g/kg/d for 28 days | Ligusticum chuanxiong Hort., Radix paeoniae rubra, Salvia miltiorrhiza Bunge, Carthamus tinctorius Linn., Dalbergia odorifera T. Chen | Increase the expression levels of VEGF and bFGF, promote angiogenesis, compensate blood supply to the heart |
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| Wang et al. [31] | 12 mice | Tongxinluo | Gavage with 0.38 g, 1.5 g/kg/d for 7/30 days | Panax ginseng C. A. Meyer, Hirudo nipponia Whitman, Scorpio, Radix paeoniae rubra, Periostracum Cicadae, Eupolyphaga Seu Steleophaga, Scolopendra subspinipes, Santalum album Linn. | Increase the expression levels of VEGF, HIF-1α, eNOS, PI3K, Akt and ERK, promote angiogenesis, improve cardiac function, ameliorate cardiac remodeling |
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| Yao [32] | ECs | Qishen Yiqi dripping pills | Drug serum for 7 days | Salvia miltiorrhiza Bunge, Astragalus membranaceus (Fisch.) Bunge, Dalbergia odorifera T. Chen, Panax notoginseng (Burk.) F. H. Chen | Increase the expression level of ERK, increase proliferation, migration and tube formation of ECs |
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| Zhang et al. [33] | 8 rats | Xuefu Zhuyu formula | Gavage with 13.68 g/kg/d for 7 days | Angelica sinensis (Oliv.) Diels, Rehmannia glutinosa Libosch, Semen Persicae, Carthamus tinctorius Linn., Radix paeoniae rubra, Bupleurum chinensis DC., Ligusticum chuanxiong Hort., Achyranthes bidentata Blume, Platycodon grandiflorus (Jacq.) A. DC. | Increase the expression level of VEGF, promote angiogenesis, protect myocardium |
| Li et al. [34] | 40 patients | 12 grains/d, po for 4 weeks | Increase levels of serum VEGF and bFGF, relieve angina and signs of blood stasis |
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| Yin et al. [35] | 24 rats | Shu-mai-tang | Gavage with 1.71 g/kg/d for 2, 4 weeks | Astragalus mongholicus Bunge, Salvia miltiorrhiza Bge, Panax notoginseng (Burk.) F.H. Chen, Hirudo nipponica Whitman, Eupolyphaga sinensis Walker, Moschus berezovskii Flerov, Trichosanthes kirilowii Maxim | Increase the expression levels of VEGF and platelet-derived growth factor, increase microvessels and arterioles in ischemic areas |
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| Xu et al. [36] | 30 rats | ShenZhuGuanXin granules | Gavage with 630, 1260, 3981.6 mg/kg/d for 4 weeks | Radix Ginseng, Radix Panacis quinquefolii, Radix Notoginseng, Hirudo, Rhizoma Pinelliae, Rhizoma Atractylodis, Folium Nelumbinis, | Increase the expression level of VEGF, increase microvessel density, attenuate infarct size, improve cardiac hemodynamic function |
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| Yang et al. [37] | 12 rats | Panax notoginseng | Gavage with 25, 50 mg/ml/d for 2 weeks | Panax Notoginseng (Burk.) F.H. Chen | Increase the expression levels of HIF-1, VEGF and VEGFR2, increase blood vessel density |
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| He et al. [38] | 15 rats | Salvianolic acid B | Gavage with 100 mg/kg/d for 4 weeks | Salvianolic acid B | Increase the expression level of VEGF, promote angiogenesis, improve myocardial microcirculation |
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| Wang et al. [39] | 8 rats | Xuesetong soft capsules | Gavage with 0.4 g/kg/d for 6 weeks | Notoginseng total saponin | Increase the expression level of VEGF, increase microvessel density |
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| Liu et al. [40] | 10 rats | Radix paeoniae rubra 801 | Gavage with 16.2 mg/kg/d for 14 days | Propyl gallate | Increase the expression levels of NO, VEGF and bFGF, increase capillary density, improve myocardial ischemia |
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| Chen et al. [41] | 25 rats | Danhong injection | Intramuscular injection with 0.76 ml/kg/d for 28 days | Radix et Rhizoma Salviae Miltiorrhizae, Flos Carthami | Increase the expression level of VEGF, increase blood vessel density, decrease ratio of infarct, improve cardiac function |
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| Zhou et al. [42] | zebrafish embryos and ECs | Spatholobi caulis | 3, 10, 30 and 100 μg/ml embryo medium for 24 h in zebrafish embryos; drug serum for 24 h in ECs | Caulis Spatholobi | Increase the expression levels of VEGFRs and MAPKs, increase subintestinal vessel sprouting, promote cell proliferation and migration, increase sprout intensity |
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