Hepatoprotective Effect of Eriobotrya japonica Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats

Table 1

Effect of various E. Japonica leaf extracts and fractions on serum marker enzymes in control and experimental rats.

Parameters	Groups
	AST; U/L	ALT; U/L	ALP; U/L	GGT; (U/L)	Bilirubin (g/dL)
Normal	107.33±3.09	26.08±1.51	341.00±7.13	5.71±0.24	0.57±0.01
CCl4	339.16±5.28^∗∗∗a	301.00±6.00^∗∗∗a	586.33±7.77^∗∗∗a	17.70±0.87^∗∗∗a	2.94±0.06^∗∗∗a
Silymarin 10 mg/kg + CCl4	154.66±4.95^∗∗∗b	88.15±6.47^∗∗∗b	396.6±711.61^∗∗∗b	7.31±0.21^∗∗∗b	1.00±0.04^∗∗∗b
Er-1 250 mg/kg + CCl4	333.66±5.25^b	295.83±5.24^b	584.50±7.96^b	15.66±0.55^b	2.95±0.04^b
Er-1 500mg/kg + CCl4	314.33±5.40^∗b	291.66±5.09^b	570.00±8.70^b	15.23±0.35^∗b	2.79±0.04^b
Er-2 250mg/kg + CCl4	278.33±6.08^∗∗∗b	196.50±6.33^∗∗∗b	492.3±5.2^∗∗∗b	12.71±0.35^∗∗∗b	1.85±0.06^∗∗∗b
Er-2 500mg/kg + CCl4	194.16±5.46^∗∗∗b	156.66±5.32^∗∗∗b	441.0±6.24^∗∗∗b	10.41±0.26^∗∗∗b	1.40±0.03^∗∗∗b
Er-3 250mg/kg + CCl4	265.50±8.55^∗∗∗b	170.16±7.21^∗∗∗b	468.0±8.1^∗∗∗b	10.11±0.24^∗∗∗b	1.81±0.07^∗∗∗b
Er-3 500mg/kg + CCl4	198.50±4.77^∗∗∗b	137.16±3.09^∗∗∗b	428.1±6.44^∗∗∗b	8.55±0.35^∗∗∗b	1.23±0.05^∗∗∗b
Er-4 250 mg/kg + CCl4	318.50±8.00^b	310.50±4.50^b	594.50±7.39^b	16.76±0.53^b	2.98±0.04^b
Er-4 500 mg/kg + CCl4	297.3±5.14^∗∗∗b	292.33±5.00^b	582.83±15.47^b	16.06±0.84^b	2.82±0.05^b

All values represent mean ± SEM. ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001; ANOVA. ^aAs compared to that of the normal control group; ^bas compared to that of the CCl₄ positive control group.