Hepatoprotective Effect of Eriobotrya japonica Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats

Table 2

Effect of E. Japonica leaf extract and fractions on metabolism and serum lipoproteins in control and experimental rats.

Parameters	Groups
	Cholesterol (mg/dL)	Triglycerides (mg/dL)	HDL; (mg/dL)	LDL; (mg/dL)	VLDL; (mg/dL)
Normal	108.3±3.08	81.88±2.41	47.56±1.14	44.39±3.09	16.37±0.48
CCl4	231.5±8.5^∗∗∗a	187.83±3.87^∗∗∗a	22.93±0.95^∗∗∗a	171.0±8.19^∗∗∗a	37.56±0.77^∗∗∗a
Silymarin 10 mg/kg + CCl4	128.5±3.5^∗∗∗b	104.51±3.56^∗∗∗b	44.6±1.30^∗∗∗b	62.9±3.5^∗∗∗b	20.90±0.77^∗∗∗b
Er-1 250 mg/kg + CCl4	223.0±4.78^b	192.83±4.85^b	24.91±0.54^b	159.5±4.3^b	38.56±0.97^b
Er-1 500 mg/kg + CCl4	211.16±4.4^b	187.5±5.2^b	26.43±0.39^∗∗b	147.23±3.76^∗b	37.50±1.04^b
Er-2 250 mg/kg + CCl4	186.1±4.5^∗∗∗b	157.5±3.7^∗∗∗b	31.4±1.0^∗∗∗b	123.1±4.7^∗∗∗b	31.50±0.74^∗∗∗b
Er-2 500 mg/kg + CCl4	155.5±4.1^∗∗∗b	137.0±3.8^∗∗∗b	38.40±0.89^∗∗∗b	89.7±4.11^∗∗∗b	27.4±0.77^∗∗∗b
Er-3 250 mg/kg + CCl4	150.3±3.3^∗∗∗b	128.6±3.4^∗∗∗b	35.41±0.88^∗∗∗b	89.1±4.19^∗∗∗b	25.72±0.76^∗∗∗b
Er-3 500 mg/kg + CCl4	129.6±8.3^∗∗∗b	125.8±3.4±^∗∗∗b	40.81±1.21^∗∗∗b	63.6±3.8^∗∗∗b	25.16±0.68^∗∗∗b
Er-4 250 mg/kg + CCl4	219.83±7.5^b	180.16±7.4^b	25.58±1.13^b	161.2±9.4^b	36.03±1.48^b
Er-4 500 mg/kg + CCl4	215.66±4.4^b	166.33±5.16^∗b	27.58±0.92^∗∗b	154.8±4.8^b	33.26±1.03^∗∗b

All values represent mean ± SEM. ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001; ANOVA, followed by Dennett’s multiple comparison test. ^aAs compared to that of the control group; ^bas compared to that of the CCl₄ positive control group.