Evidence-Based Complementary and Alternative Medicine

Research Article

Hepatoprotective Effect of Eriobotrya japonica Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats

Table 3

Effect of E. japonica leaf extract and fractions on MDA, NP-SH, and total protein levels in liver tissues.


Treatments	MDA (nmol/g)	NP-SH (nmol/g)	Total Protein (g/L)

Normal	1.11±0.04	6.33±0.28	121.35±3.36
CCl₄	7.43±0.29^∗∗∗a	1.41±0.21^∗∗∗a	59.48±1.89^∗∗∗a
Silymarin (10 mg/kg) + CCl₄	2.15±0.09^∗∗∗b	5.91±0.26^∗∗∗b	106.98±2.28^∗∗∗b
Er-1 (250 mg/kg) + CCl₄	6.76±0.38^b	1.77±0.29^b	59.88±2.31^b
Er-1 (500 mg/kg) + CCl₄	5.59±0.24^∗∗∗b	2.20±0.25^∗b	66.66±1.68^∗b
Er-2 (250 mg/kg) + CCl₄	4.25±0.18^∗∗∗b	4.81±0.21^∗∗∗b	73.45±1.00^∗∗∗b
Er-2 (500 mg/kg) + CCl₄	3.60±0.12^∗∗∗b	5.13±0.28^∗∗∗b	81.83±1.89^∗∗∗b
Er-3 (250 mg/kg) + CCl₄	3.60±0.19^∗∗∗b	5.31±0.13^∗∗∗b	77.44±2.59^∗∗∗b
Er-3 (500 mg/kg) + CCl₄	2.79±0.10^∗∗∗b	5.00±0.27^∗∗∗b	95.80±2.83^∗∗∗b
Er-4 (250 mg/kg) + CCl₄	6.87±0.3^b	1.52±0.2^b	58.68±1.60^b
Er-4 (500 mg/kg) + CCl₄	5.52±0.21^∗∗∗b	2.50±0.28^∗b	67.46±1.43^∗∗b

All values represent mean ± SEM. ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001; ANOVA, followed by Dennett’s multiple comparison test. ^aAs compared to that of the control group; ^bas compared to that of the CCl₄ positive control group.