Induction of Apoptosis and Inhibition of Epithelial Mesenchymal Transition by α-Mangostin in MG-63 Cell Lines

Figure 4

α-Mangostin stimulated caspase cascade associated with mitochondrial function. Cells were treated with various concentration of α-mangostin (0, 10, 25, and 50 μM) for 24 h. (a) Procaspase-9, procaspase-7, procaspase-3, cleaved caspase-3, and PARP proteins expressions were detected by western blot analysis. The β-actin was used as an internal standard. (b) Quantification of proteins expressions was performed by image J. versus untreated cells (control).

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