Hypoglycemic Properties of the Aqueous Extract from the Stem Bark of Ceiba pentandra in Dexamethasone-Induced Insulin Resistant Rats
Table 2
Effect of repeated administration of the decoction of Ceiba pentandra (DCP) and metformin on catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) concentrations in the liver, heart, and aorta.
Parameters assayed
Organs
Control
Dexamethasone (1 mg/kg/day, i.m)
Distilled water
DCP 75
DCP 150
Metformin
Proteins (mg/g of tissue)
Liver
235,74 ± 19,15
187,10 ± 13,61
204,49 ± 9,40
271,31 ± 7,70
257,05 ± 25,68
Heart
82,33 ± 3,88
71,25 ± 3,25
88,24 ± 10,27
83,86 ± 2,10
81,14 ± 3,12
Aorta
33,91 ± 3,60
26,76 ± 1,67
27,86 ± 2,01
27,13 ± 1,98
33,91 ± 2,96
Catalase (activity/g of protein)
Liver
0.098 ± 0.014
0.135 ± 0.020
0.171 ± 0.024
0.150 ± 0.018
0.028 ± 0.007
Heart
0.446 ± 0.022
0.457 ± 0.011
0.954 ± 0.175
0.874 ± 0.110
0.852 ± 0.142
Aorta
8.378 ± 1.433
8.505 ± 0.741
8.679 ± 0.650
8.736 ± 0.846
7.215 ± 0.510
SOD (μmol/g of protein)
Liver
0.036 ± 0.007
0.083 ± 0.024
0.043 ± 0.007
0.043 ± 0.011
0.035 ± 0.008
Heart
0.173 ± 0.041
0.150 ± 0.020
0.151 ± 0.026
0.154 ± 0.047
0.187 ± 0.051
Aorta
0.397 ± 0.118
0.680 ± 0.095
0.645 ± 0.089
0.704 ± 0.118
0.622 ± 0.030
GSH (μmol/g of protein)
Liver
10,932 ± 0,397
7,37 ± 1,756
10,758 ± 2,34
9,203 ± 2,052
8,777 ± 0,514
Heart
9,316 ± 1,366
9,123 ± 2,000
8,964 ± 1,188
9,409 ± 3,857
9,416 ± 1,827
Aorta
0,413 ± 0,056
0,486 ± 0,120
0,431 ± 0,050
0,405 ± 0,101
0,324 ± 0,034
MDA (μmol/g of tissue)
Liver
0.021 ± 0.001
0.020 ± 0.001
0.020 ± 0.002
0.017 ± 0.002
0.019 ± 0.001
Heart
0.006 ± 0.001
0.007 ± 0.001
0.009 ± 0.001
0.009 ± 0.001
0.008 ± 0.001
Aorta
0.001 ± 0.001
0.001 ± 0.003
0.004 ± 0.003
0.005 ± 0.001
0.003 ± 0.002
NO (μmol/g of tissue)
Liver
0,535 ± 0,038
0,437 ± 0,032
0,574 ± 0,061
0,681 ± 0,107
1,208 ± 0,115
Heart
0.098 ± 0.012
0.056 ± 0.006
0.096 ± 0.027
0.089 ± 0.012
0.083 ± 0.012
Values expressed as mean ± SEM; P<0.05; P<0.01, with respect to control group. P<0.05, P<0.01, P<0.001, with respect to dexamethasone group.
