Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori
Table 2
Serum biochemical values in rats orally treated with Wei Bi Mei at withdrawal at 0, 4, 8, and 12 weeks after bismuth exposure.
Parameter
Time
0
4 w
8 w
12 w
Wei Bi Mei
Water
Wei Bi Mei
Water
Wei Bi Mei
Water
Wei Bi Mei
Water
ALT (U/L)
40 (6)
38 (3)
42 (4)
47 (6)
43 (5)
41 (6)
41 (3)
42 (3)
AST (U/L)
100 (27)
134 (23)
110 (39)
116 (29)
97 (31)
82 (10)
112 (25)
109 (21)
ALP (U/L)
163 (24)
183 (67)
206 (57)
207 (50)
150 (29)
153 (31)
155 (30)
172 (77)
GLU (mmol/L)
5.8 (0.9)
5.2 (0.4)
5.45 (0.8)
5.6 (0.5)
5.85 (0.8)
5.2 (0.3)
5.2 (0.4)
5.4 (0.4)
TP (g/L)
56 (6)
56 (3)
55 (4)
55 (3)
53 (3)
57 (4)
54 (5)
54 (3)
ALB (g/L)
28 (2)
29 (20)
29 (2)
28 (3)
28 (1)
27 (2)
28 (1)
30 (2)
T-BIL (µmol/L)
7.35 (1.89)
7.26 (1.96)
7.48 (1.44)
6.68 (1.25)
6.58 (1.78)
7.95 (1.01)
7.21 (1.13)
7.47 (1.38)
D-BIL (µmol/L)
4.01 (0.94)
4.6 (1.32)
3.98 (1.37)
4.06 (0.72)
3.75 (1.16)
5.28 (0.49)
3.93 (0.91)
4.08 (0.96)
Cre (µmol/L)
38 (5)
40 (3)
36 (5)
33 (8)
30 (6)
33 (6)
36 (5)
37 (4)
Bun (mmol/L)
5.70 (1.25)
6.00 (1.26)
6.03 (0.83)
6.57 (0.98)
6.21 (1.65)
7.28 (2.47)
5.91 (0.667)
6.38 (1.16)
Na+ (mmol/L)
141.2 (4.7)
144.3 (2.0)
143.4 (4.1)
143.9 (1.73)
141.4 (2.9)
141.7 (2.5)
140 (4.0)
139 (1.4)
K+ (mmol/L)
4.23 (0.39)
4.31 (0.43)
4.62 (0.49)
4.59 (0.47)
4.58 (0.48)
4.30 (0.34)
4.11 (0.31)
4.56 (0.33)
Cl- (mmol/L)
100.2 (4.2)
97.7 (2.1)
103.5 (5.2)
96.5 (1.9)
100.7 (4.7)
96.8 (1.5)
99.6 (4.7)
100.4 (1.7)
Alanine aminotransferase activity (ALT), aspartate aminotransferase activity (AST), alkaline phosphatase activity (ALP), glucose (GLU), total protein (TP), albumin (ALB), total bilirubin (T-BIL), direct bilirubin (D-BIL), creatinine (CRE), blood urea nitrogen (BUN), potassium ions (K+), sodium ions (Na+), and chloride ions (Cl-). Colloidal bismuth subcitrate (CBS); values are mean (SD); and when compared to the controls using the independent -test.
