Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori
Table 3
Serum biochemical values in rats orally treated with bismuth aluminate at withdrawal at 0, 4, 8, and 12 weeks after bismuth exposure.
Parameter
Time
0
4 w
8 w
12 w
Bismuth aluminate
Water
Bismuth aluminate
Water
Bismuth aluminate
Water
Bismuth aluminate
Water
ALT (U/L)
40 (3)
38 (3)
45 (3)
47 (6)
38 (5)
41 (6)
39 (3)
42 (3)
AST (U/L)
128 (24)
134 (23)
94 (35)
116 (29)
95 (14)
82 (10)
97 (23)
109 (21)
ALP (U/L)
139 (51)
183 (67)
174 (79)
207 (50)
169 (59)
153 (31)
172 (77)
172 (77)
GLU(mmol/L)
5.31 (0.9)
5.2 (0.4)
5.76 (5.55)
5.6 (0.5)
5.55 (0.81)
5.2 (0.3)
5.4 (0.5)
5.4 (0.4)
TP (g/L)
53 (3)
56 (3)
55 (4)
55 (3)
56 (3)
57 (4)
54 (3)
54 (3)
ALB (g/L)
27 (2)
29 (2)
29 (2)
28 (3)
28 (2)
27 (2)
30 (1)
30 (2)
T-BIL(µmol/L)
7.03 (2.01)
7.26 (1.96)
7.2 (1.59)
6.68 (1.25)
7.08 (1.47)
7.95 (1.01)
7.30 (1.21)
7.47 (1.38)
D-BIL(µmol/L)
4.20 (1.09)
4.60 (1.32)
4.70 (1.27)
4.06 (0.72)
4.08 (1.05)
5.28 (0.49)
4.02 (0.73)
4.08 (0.96)
Cre (µmol/L)
41 (4)
40 (3)
31 (5)
33 (8)
32 (10)
33 (6)
36 (4)
37 (4)
Bun (mmol/L)
5.63 (0.70)
6.00 (1.26)
7.51 (0.71)
6.57 (0.98)
6.09 (1.03)
7.28 (2.47)
5.85 (0.99)
6.38 (1.16)
Na+ (mmol/L)
143 (1.8)
144 (2.0)
140 (1.2)
143.9 (1.73)
142.7 (2.9)
142 (2.5)
143 (2.4)
139 (1.4)
K+ (mmol/L)
5.00 (0.25)
4.31 (0.43)
4.67 (0.35)
4.59 (0.47)
4.02 (0.33)
4.30 (0.34)
4.47 (0.35)
4.56 (0.33)
Cl- (mmol/L)
102 (5.1)
97.7 (2.1)
101 (4.6)
96.5 (1.9)
96.9 (3.4)
96.8 (1.5)
98.3 (3.2)
100 (1.7)
Alanine aminotransferase activity (ALT), aspartate aminotransferase activity (AST), alkaline phosphatase activity (ALP), glucose (GLU), total protein (TP), albumin (ALB), total bilirubin (T-BIL), direct bilirubin (D-BIL), creatinine (CRE), blood urea nitrogen (BUN), potassium ions (K+), sodium ions (Na+), and chloride ions (Cl-). Colloidal bismuth subcitrate (CBS); values are mean (SD); and when compared to the controls using the independent -test.
