Anti-Inflammatory Effect of ETAS®50 by Inhibiting Nuclear Factor-κB p65 Nuclear Import in Ultraviolet-B-Irradiated Normal Human Dermal Fibroblasts

Figure 2

Effect of NF-κB inhibitor JSH-23 or ETAS on UV-B irradiation-induced IL-1β mRNA expression in NHDFs. (a) Effect of JSH-23 on UV-B-induced IL-1β mRNA expression in the cells. The cells were treated with 10 μM JSH-23 or DMSO alone for 24 h after UV-B irradiation (20 mJ/cm²). (b) Effect of ETAS on UV-B-induced IL-1β mRNA expression in the cells. The cells were treated with 1 mg/mL ETAS or dextrin for 24 h after UV-B irradiation (20 mJ/cm²). IL-1β mRNA levels were analyzed by real-time PCR. The relative ratios of IL-1β to 18S are shown. Means ± SEM (n = 3). p < 0.05, p < 0.01 (by one-way ANOVA and Tukey’s test).

(a)

(b)