A Validated LC-MS/MS Method for Simultaneous Determination of Six Aconitum Alkaloids and Seven Ginsenosides in Rat Plasma and Application to Pharmacokinetics of Shen-Fu Prescription

Table 6

Pharmacokinetic parameters of the six Aconitum alkaloids and seven ginsenosides after oral administration of Shen-Fu prescription (n=8).

Compounds	(h)	(ng mL^−1)	t1/2 (h)	(h·ng mL^−1)	(h·ng mL^−1)	(h)	(h)
AC	0.87 ± 0.67	0.91 ± 0.40	3.07 ± 1.31	4.13 ± 1.28	4.26 ± 1.36	4.65 ± 1.31	5.22 ± 1.57
MA	0.87 ± 0.67	2.00 ± 1.15	3.07 ± 2.05	7.33 ± 2.38	7.97 ± 2.01	4.34 ± 1.10	4.79 ± 2.58
HA	0.87 ± 0.67	17.96 ± 6.89	4.02 ± 1.02	114.69 ± 21.46	123.54 ± 28.09	7.47 ± 2.74	8.16 ± 4.95
BAC	0.29 ± 0.17	6.56 ± 3.32	1.10 ± 0.68	23.34 ± 13.01	24.93 ± 14.82	12.29 ± 6.23	14.14 ± 6.27
BMA	0.25 ± 0.14	27.40 ± 16.27	1.09 ± 0.71	101.72 ± 73.24	114.96 ± 82.38	9.39 ± 4.70	10.34 ± 5.10
BHA	0.18 ± 0.06	28.96 ± 15.83	0.54 ± 0.37	119.00 ±82.80	123.92 ± 80.97	8.98 ± 4.21	10.11 ± 3.90
Rb1	22.91 ± 3.62	164.85 ± 33.22	14.29 ± 1.60	6536.09 ± 1602.23	6601.72 ± 1606.56	30.37 ± 1.37	31.58 ± 1.61
Rb2	28.00 ± 6.20	59.70 ± 15.60	19.65 ± 3.24	2965.44 ± 752.25	3167.67 ± 700.86	39.77 ± 2.51	50.06 ± 8.34
Rc	22.54 ± 4.82	58.98 ± 23.16	16.97 ± 2.02	2558.56 ± 824.52	2614.91 ± 825.03	35.98 ± 2.09	37.83 ± 2.36
Rd	22.29 ± 4.54	51.23 ± 30.78	17.68 ± 8.31	1794.84 ± 839.20	1868.61 ± 820.37	35.27± 5.49	40.37 ± 10.10
Re	0.26 ± 0.12	27.72 ± 10.22	14.62 ± 9.40	242.21 ± 97.15	278.46 ± 87.95	16.49 ± 2.63	19.96 ± 3.35
Rg1	0.24 ± 0.15	37.61 ± 18.98	15.82 ± 10.83	242.85 ± 172.14	261.81 ± 168.63	16.26 ± 6.73	19.58 ± 9.00