| | Pathway | Target |
| | Pathways in cancer | E2F1, E2F2, PPARD, PTGS2, MMP9, PPARG, PTEN, MMP2, TGFB1, MMP1, AKT1, FOS, CASP3, CASP9, CASP8, NOS2, MYC, CHUK, PRKCA, EGFR, PIK3CG, AR, RXRB, RELA, RXRA, RUNX1T1, TP53, RB1, CDK2, MAPK1, CCND1, HIF1A, JUN, MAPK3, VEGFA, MDM2, MAPK8, ERBB2, EGLN1, BCL2L1, BCL2, NKX3-1, EGF, IL6, MET, RAF1, BIRC5, MAPK10, STAT1, STAT3, CDKN1A, GSK3B, RASSF1, BAX, IKBKB | | Non-small cell lung cancer | PRKCA, E2F1, EGFR, PIK3CG, E2F2, RXRB, RXRA, ERBB2, TP53, RAF1, RB1, AKT1, MAPK1, CCND1, CASP9, RASSF1, MAPK3, EGF | | Colorectal cancer | EGFR, PIK3CG, MET, TP53, RAF1, BIRC5, MAPK10, TGFB1, AKT1, MAPK1, FOS, CASP3, CCND1, CASP9, GSK3B, JUN, BAX, BCL2, MAPK3, MAPK8, MYC | | Small cell lung cancer | E2F1, PIK3CG, E2F2, PTGS2, RXRB, RXRA, RELA, TP53, RB1, BCL2L1, PTEN, CDK2, AKT1, CCND1, CASP9, BCL2, NOS2, IKBKB, MYC, CHUK | | Toll-like receptor signaling pathway | PIK3CG, IL6, TNF, RELA, MAPK10, CXCL11, STAT1, CXCL10, AKT1, MAPK1, FOS, MAPK14, JUN, MAPK3, CASP8, IL1B, MAPK8, IKBKB, CHUK, SPP1 | | VEGF signaling pathway | PRKCA, PIK3CG, PTGS2, RAF1, KDR, AKT1, MAPK1, PLA2G4A, CASP9, MAPK14, VEGFA, MAPK3, HSPB1, NOS3, PPP3CA, PLA2G2E, NFATC1 | | T cell receptor signaling pathway | IL4, PIK3CG, TNF, RELA, RAF1, IL10, AKT1, MAPK1, FOS, CD40LG, MAPK14, GSK3B, JUN, IFNG, MAPK3, PPP3CA, IKBKB, CHUK, NFATC1, IL2 | | Apoptosis | PIK3CG, TNF, RELA, TP53, BCL2L1, AKT1, CASP3, CASP9, BAX, CASP7, BCL2, CASP8, IL1B, PRKACA, PPP3CA, IKBKB, CHUK, IL1A | | ErbB signaling pathway | PRKCA, EGFR, PIK3CG, ERBB3, ERBB2, RAF1, ELK1, MAPK10, AKT1, MAPK1, CDKN1A, GSK3B, JUN, MAPK3, MAPK8, EGF, MYC | | Insulin signaling pathway | SREBF1, PIK3CG, HK2, ACACA, RAF1, ELK1, PDE3A, IGF2, MAPK10, AKT1, MAPK1, SLC2A4, PYGM, GSK3B, MAPK3, FASN, MAPK8, PRKACA, PTPN1, IKBKB, INSR | | p53 signaling pathway | TP53, CHEK1, CHEK2, PTEN, CDK2, CCNB1, CDKN1A, CASP3, CCND1, CASP9, BAX, CASP8, SERPINE1, MDM2, IGFBP3 | | NOD-like receptor signaling pathway | IL6, CCL2, TNF, RELA, CXCL2, MAPK10, MAPK1, MAPK14, MAPK3, CASP8, IL1B, MAPK8, IKBKB, CHUK | | Progesterone-mediated oocyte maturation | PIK3CG, ADCY2, RAF1, PDE3A, IGF2, MAPK10, CDK2, AKT1, CCNB1, PGR, MAPK1, MAPK14, MAPK3, PRKACA, MAPK8, CCNA2 | | MAPK signaling pathway | TNF, ELK1, TGFB1, AKT1, FOS, CASP3, IL1B, PRKACA, PPP3CA, EGF, MYC, CHUK, IL1A, RASA1, EGFR, PRKCA, RELA, TP53, RAF1, MAPK10, MAPK1, PLA2G4A, MAPK14, JUN, MAPK3, HSPB1, MAPK8, PLA2G2E, IKBKB | | Focal adhesion | PRKCA, EGFR, PIK3CG, CAV1, ERBB2, MET, COL3A1, ELK1, RAF1, MAPK10, PTEN, KDR, AKT1, MAPK1, CCND1, GSK3B, JUN, BCL2, VEGFA, MAPK3, MAPK8, COL1A1, EGF, SPP1 | | Calcium signaling pathway | PRKCA, EGFR, PIK3CG, CAV1, ERBB2, MET, COL3A1, ELK1, RAF1, MAPK10, PTEN, KDR, AKT1, MAPK1, CCND1, GSK3B, JUN, BCL2, VEGFA, MAPK3, MAPK8, COL1A1, EGF, SPP1PRKCA, EGFR, DRD1, ADCY2, PTGER3, ERBB3, ERBB2, CHRM5, ADRB2, ADRB1, CHRM3, CHRM2, CHRM1, ADRA1B, ADRA1A, NOS3, CHRNA7, PRKACA, PPP3CA, NOS2, HTR2C, ADRA1D, HTR2A | | GnRH signaling pathway | PRKCA, EGFR, ADCY2, RAF1, ELK1, MAPK10, MMP2, PRKCD, MAPK1, PLA2G4A, MAPK14, JUN, MAPK3, PRKACA, MAPK8, PLA2G2E | | Fc epsilon RI signaling pathway | PRKCA, IL4, PIK3CG, TNF, RAF1, MAPK10, PRKCD, AKT1, MAPK1, PLA2G4A, MAPK14, MAPK3, MAPK8, PLA2G2E | | Adipocytokine signaling pathway | PPARA, TNF, RXRB, RXRA, RELA, MAPK10, ADIPOQ, STAT3, AKT1, SLC2A4, MAPK8, IKBKB, CHUK | | B cell receptor signaling pathway | PIK3CG, AKT1, MAPK1, FOS, RELA, JUN, GSK3B, MAPK3, RAF1, PPP3CA, IKBKB, CHUK, NFATC1 | | Steroid hormone biosynthesis | AKR1C3, CYP3A4, HSD3B2, CYP1B1, HSD3B1, CYP1A1, SULT1E1, UGT1A1, AKR1C1, CYP19A1 | | Neurotrophin signaling pathway | PIK3CG, RELA, TP53, RAF1, MAPK10, PRKCD, AKT1, MAPK1, MAPK14, GSK3B, JUN, BAX, BCL2, MAPK3, MAPK8, IKBKB | | Cell cycle | E2F1, E2F2, TP53, CHEK1, RB1, CHEK2, TGFB1, CDK2, CCNB1, CCND1, CDKN1A, GSK3B, PCNA, MDM2, MYC, CCNA2 | | Chemokine signaling pathway | PIK3CG, ADCY2, CCL2, NCF1, RELA, CXCL2, RAF1, STAT1, CCL16, CXCL11, PRKCD, STAT3, CXCL10, AKT1, MAPK1, GSK3B, MAPK3, PRKACA, IKBKB, CHUK | | Neuroactive ligand-receptor interaction | OPRM1, DRD1, GABRA2, GABRA1, PTGER3, GABRA3, GABRA5, PRSS1, CHRM5, ADRB2, ADRB1, CHRM4, CHRM3, GRIA2, CHRM2, CHRM1, F2, ADRA1B, ADRA2A, ADRA1A, ADRA2C, HTR2C, ADRA1D, HTR2A, OPRD1 | | Gap junction | PRKCA, EGFR, DRD1, ADCY2, GJA1, RAF1, MAPK1, ADRB1, MAPK3, PRKACA, EGF, HTR2C, HTR2A | | Metabolism of xenobiotics by cytochrome P450 | GSTM1, AKR1C3, CYP3A4, GSTM2, CYP1B1, CYP1A1, ADH1C, CYP1A2, UGT1A1, AKR1C1 | | Epithelial cell signaling in Helicobacter pylori infection | EGFR, CASP3, RELA, MAPK14, JUN, MET, MAPK8, MAPK10, IKBKB, CHUK | | Vascular smooth muscle contraction | PRKCA, KCNMA1, MAPK1, PLA2G4A, ADCY2, MAPK3, ADRA1B, ADRA1A, RAF1, PRKACA, PLA2G2E, PRKCD, ADRA1D | | Arachidonic acid metabolism | AKR1C3, PLA2G4A, PTGS2, PTGES, PTGS1, LTA4H, ALOX5, PLA2G2E, ALOX12 | | PPAR signaling pathway | PPARA, PPARD, OLR1, RXRB, RXRA, PPARG, ADIPOQ, MMP1, FABP5 | | RIG-I-like receptor signaling pathway | TNF, RELA, MAPK14, CASP8, MAPK8, MAPK10, IKBKB, CHUK, CXCL10 | | Cytokine-cytokine receptor interaction | EGFR, IL4, IL6, TNF, CCL2, MET, CXCL2, CCL16, CXCL11, IL10, TGFB1, CXCL10, KDR, CD40LG, VEGFA, IFNG, IL1B, EGF, IL1A, IL2 | | Drug metabolism | GSTM1, CYP3A4, GSTM2, MAOA, MAOB, ADH1C, CYP1A2, UGT1A1 | | Wnt signaling pathway | PRKCA, CCND1, PPARD, GSK3B, JUN, TP53, MAPK8, PRKACA, PPP3CA, MAPK10, MYC, FOSL1, NFATC1 | | mTOR signaling pathway | PIK3CG, AKT1, MAPK1, HIF1A, MAPK3, VEGFA, IGF2 | | Complement and coagulation cascades | PLAT, F10, THBD, F3, F2, SERPINE1, F7, PLAU | | Jak-STAT signaling pathway | PIK3CG, IL4, AKT1, IL6, CCND1, IFNG, PIM1, BCL2L1, STAT1, MYC, IL10, STAT3, IL2 | | Tryptophan metabolism | CYP1B1, CYP1A1, MAOA, MAOB, CYP1A2, CAT | | Aldosterone-regulated sodium reabsorption | PRKCA, PIK3CG, MAPK1, MAPK3, IGF2, INSR | | Oocyte meiosis | CCNB1, PGR, MAPK1, AR, ADCY2, MAPK3, IGF2, PRKACA, PPP3CA, CDK2 | | Fc gamma R-mediated phagocytosis | PRKCA, PIK3CG, AKT1, MAPK1, PLA2G4A, NCF1, MAPK3, RAF1, PRKCD | | Natural killer cell mediated cytotoxicity | PRKCA, PIK3CG, ICAM1, MAPK1, CASP3, TNF, MAPK3, IFNG, RAF1, PPP3CA, NFATC1 | | Intestinal immune network for IgA production | IL4, IL6, CD40LG, IL10, TGFB1, IL2 | | Long-term depression | PRKCA, MAPK1, PLA2G4A, GRIA2, MAPK3, RAF1, PLA2G2E | | Androgen and estrogen metabolism | HSD3B2, HSD3B1, SULT1E1, UGT1A1, CYP19A1 | | Arginine and proline metabolism | ODC1, GOT1, MAOA, MAOB, NOS3, NOS2 | | Cytosolic DNA-sensing pathway | IL6, RELA, IL1B, IKBKB, CHUK, CXCL10 | | Adherens junction | EGFR, MAPK1, ERBB2, MET, MAPK3, PTPN1, INSR | | Leukocyte transendothelial migration | PRKCA, PIK3CG, VCAM1, ICAM1, CLDN4, NCF1, MAPK14, MMP9, MMP2 | | Tyrosine metabolism | TYR, GOT1, MAOA, MAOB, ADH1C | | Linoleic acid metabolism | CYP3A4, PLA2G4A, CYP1A2, PLA2G2E |
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