Apocynum venetum Leaf Extract Exerts Antidepressant-Like Effects and Inhibits Hippocampal and Cortical Apoptosis of Rats Exposed to Chronic Unpredictable Mild Stress

Figure 2

Effect of AVLE on depressive behavior in CUMS rats. (a) Effect of AVLE administration on body weight of CUMS rats. (b) Effect of AVLE administration on sucrose preference in CUMS rats. (c) Effect of AVLE administration on immobility time during forced swimming test in CUMS rats. (d) Trace plot of open field test. (e) Effect of AVLE administration on time spent in the center area during open field test in CUMS rats. (f) Effect of AVLE administration on total distance moved during open field test in CUMS rats. Data are expressed as mean ± SEM (); , , and compared with the control group; and compared with the CUMS group. CON: control; CUMS: chronic unpredictable mild stress; FLX: fluoxetine; AVLE30: Apocynum venetum leaf extract (30 mg/kg); AVLE60: Apocynum venetum leaf extract (60 mg/kg); AVLE120: Apocynum venetum leaf extract (120 mg/kg).

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