Drug-Repositioning Approach for the Discovery of Anti-Influenza Virus Activity of Japanese Herbal (Kampo) Medicines<i> In Vitro</i>: Potent High Activity of Daio-Kanzo-To

<div>The quantity of crude drugs for Kampo medicines and their anti-influenza virus activity. The quantity of crude drugs (g) for daily dose in Daio-kanzo-to (TJ-84), Mao-to (EK-27, TJ-27, and N27), Bofu-tsusho-san (TJ-62), Kakkon-to (TJ-1), and Dai-kenchu-to (TJ-100) are shown. Crude drugs in the herbal medicine library were used in the screening. Crude drugs were added to MDCK cells in the presence of influenza virus A/WSN/33 and incubated for 48 h. The cells were fixed and stained with CV. Relative anti-influenza virus activities of crude drugs at 100 and 10 <i>μ</i>g/mL are shown as closed and open boxes, respectively. Crude drugs with antiviral activities &gt;30% were considered positive results. Average values and standard deviation from two independent experiments are shown.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 3: Drug-Repositioning Approach for the Discovery of Anti-Influenza Virus Activity of Japanese Herbal (Kampo) Medicines<i> In Vitro</i>: Potent High Activity of Daio-Kanzo-To 

Figure 3 | Drug-Repositioning Approach for the Discovery of Anti-Influenza Virus Activity of Japanese Herbal (Kampo) Medicines In Vitro: Potent High Activity of Daio-Kanzo-To 