Supplementation of Stingless Bee Honey from Heterotrigona itama Improves Antiobesity Parameters in High-Fat Diet Induced Obese Rat Model

Figure 3

Photomicrographs show the effects of three different treatments and dosages of stingless bee honey (SBH) in liver tissue of obese rats, under a scanning electron microscope (ScEM) at 2500x magnification. (a) Group 1, normal architecture of liver surface (normal sinusoid and intact hepatocytes); (b) Group 2, obese rats’ liver fed with HFD received no treatment showed presence of fat cells and have damage hepatocytes, damage sinusoid and rough surface; (c) Group 3, obese rats’ liver fed with HFD and treated with 1000 mg/kg SBH showed fibrin formation, dilated sinusoid, and nonintact hepatocytes; (d) Group 4, obese rats’ liver fed with HFD and treated with 750 mg/kg SBH showed smooth appearance and a few insignificant presence of fat cells; (e) Group 5, obese rats’ liver fed with HFD and treated with 500 mg/kg SBH showed normal-like structure and a few insignificant presence of fat cells. Fat cells are indicated in red circles. H= hepatocyte; S= sinusoid.

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