ROS-Mediated Mitochondrial Pathway is Required for Manilkara Zapota (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-κB Activities of HeLa Human Cervical Cancer Cells

<div>Apoptotic activities of Manilkara zapota leaf methanol extract on HeLa cells after 72 h incubation. HeLa cells treated with 12 and 48 μg/mL of Manilkara zapota leaf methanol extract upregulated apoptotic protein expression of (a) Bax and downregulated (b) Bcl-2, respectively. (c) Manilkara zapota leaf methanol extract-induced caspase-3 activation. Values are reported as mean ± SD (n = 3). Value with different superscript letter indicates significant difference between groups by Tukey’s test (P &lt; 0.05).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 6

Figure 6: ROS-Mediated Mitochondrial Pathway is Required for Manilkara Zapota (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-κB Activities of HeLa Human Cervical Cancer Cells

Figure 6 | ROS-Mediated Mitochondrial Pathway is Required for Manilkara Zapota (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-κB Activities of HeLa Human Cervical Cancer Cells 