Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models

Table 2

Observations in the acute toxicity test after oral administration of PEE. EAE and HEE of T. monadelpha in mice.

PEE				EAE				HEE
Dose; (mg/kg)	Mortality; D/T	Latency; (min)	Observed drug effects	Dose; (mg/kg)	Mortality; D/T	Latency; (min)	Observed drug effects	Dose; (mg/kg)	Mortality; D/T	Latency; (min)	Observed drug effects
0	-	-	-	0	-	-	-	0	-	-	-
30	-	30	Analgesia, urination, defecation	30	-	30	Analgesia, urination, defecation	30	-	30	Analgesia, urination, defecation
100	-	15	Analgesia, urination, defecation	100	-	30	Analgesia, urination, defecation	100	-	30	Analgesia, urination, defecation
300	-	15	Sedation analgesia, urination, defecation	300	-	30	Sedation analgesia, urination, defecation	300	-	30	Sedation, analgesia, urination, defecation
1000	-	15	Sedation, analgesia, urination, defecation	1000	-	15	Sedation, analgesia, urination, defecation	1000	-	15	Sedation, analgesia, urination, defecation
3000	-	15	Sedation, analgesia, urination, defecation	3000	-	15	Sedation, analgesia, urination, defecation	3000	-	30	Sedation, analgesia, urination, defecation