Development of Novel Photosensitizer Using the Buddleja officinalis Extract for Head and Neck Cancer

Figure 2

BO-PDT-induced cell death in FaDu cells. (a) The fluorescence values of BO extract and hematoporphyrin (HP) at 1, 10, 100, and 500 μg/mL. The maximum value that could be measured by a microplate fluorescence reader was represented as 100,000 units. The cytotoxicity of FaDu cell treatment with BO extract and 625 nm LED light (BO-PDT). (b) The effects of BO-PDT at BO extract concentrations of 5, 10, 20, and 40 μg/mL are shown. (c) BO-PDT decreased cell viability in a time-dependent manner. Nontreated condition versus BO: # P < 0.05; ## P < 0.001; BO versus BO-PDT: P < 0.05; P < 0.01.

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