A Phenolic Fraction from Catharanthus roseus L. Stems Decreases Glycemia and Stimulates Insulin Secretion

Table 2

Effect of the aqueous alkaloid-free extract of C. roseus and its fractions in normal mice.

Treatment	Dose	Blood glucose reduction ()
		2 h	4 h	6 h
Saline solution	4 mL/kg	5.8 ± 2.55	6.6 ± 1.25	-5.7 ± 1.49
Glibenclamide	10 mg/kg	14.9 ± 2.11	32.6 ± 0.57	1.7 ± 2.06
Aqueous alkaloid-free extract	125 mg/kg	0.8 ± 1.18	13.0 ± 1.51	23.5 ± 1.60
	250 mg/kg	17.9 ± 3.85	35.3 ± 2.65	25.0 ± 8.29
	500 mg/kg	3.7 ± 4.04	46.0 ± 1.6	53.2 ± 1.5
Aqueous fraction	250 mg/kg	-26.3 ± 7.83	25.6 ± 6.15	22.3 ± 5.58
Organic fraction	250 mg/kg	-29.2 ± 5.53	1.3 ± 5.68	31.6 ± 5.64
Precipitate	250 mg/kg	-33.5 ± 6.2	7.2 ± 3.35	48.1 ± 1.55

Values are the mean percentage of blood glucose reduction (±S.E.M.). indicates significant differences compared with fasting glycemia (p < 0.05), n=5.