Effect of Fermented Spirulina maxima Extract on Cognitive-Enhancing Activities in Mice with Scopolamine-Induced Dementia

Table 1

Effect of the fermented extracts on the inhibition of acetylcholine esterase (AChE) activities in the hippocampus of mice with scopolamine-induced memory impairment.

Groups	AChE activity (U/mg protein)
Control	0.65±0.012
Scopolamine	0.91±0.022^#
Donepezil	0.61±0.039
Fermented S. maxima extract (50 mg/kg)	0.83±0.018^#
Fermented S. maxima extract (100 mg/kg)	0.77±0.020
Fermented S. maxima extract (200 mg/kg)	0.69±0.051
Fermented S. maxima extracts (400 mg/kg)	0.68±0.045
β-carotene (1 mg/kg)	0.75±0.019^#
β-carotene (5 mg/kg)	0.70±0.033

The values shown are the mean escape latency time ± SD (n=6). p<0.05, p<0.01, and p<0.001 significant in comparison to scopolamine group (n=6). ^#p<0.05, ^##p<0.01, and ^###p<0.001 significant in comparison to control group (n=6).