In Vitro Antioxidant Potential and Effect of a Glutathione-Enhancer Dietary Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity

Figure 2

(a) Effect of CellGevity dietary supplement on CYP1A1/1A2 activity in rat liver microsomes. Negative control (NC; distilled water), positive control (PC; phenobarbitone 80 mg/kg), low dose treatment (LDT; 4 mg/kg supplement), and high dose treatment (HDT; 8 mg/kg supplement). Data represent mean ± standard deviations. and are values statistically different as indicated with and , respectively. (b) Effect of CellGevity dietary supplement on CYP1A2 activity in rat liver microsomes. Negative control (NC; distilled water), positive control (PC; phenobarbitone 80 mg/kg), low dose treatment (LDT; 4 mg/kg supplement), and high dose treatment (HDT; 8 mg/kg supplement). Data represent mean ± standard deviations. and are values statistically different as indicated with and , respectively. (c) Effect of CellGevity dietary supplement on CYP2B1/2B2 activity in rat liver microsomes. Negative control (NC; distilled water), positive control (PC; phenobarbitone 80 mg/kg), low dose treatment (LDT; 4 mg/kg supplement), and high dose treatment groups (HDT; 8 mg/kg supplement). Data represent mean ± standard deviations. and are values statistically different as indicated with and , respectively. (d) Effect of CellGevity dietary supplement on CYP3A4 activity in rat liver microsomes. Negative control (NC; distilled water), positive control (PC; phenobarbitone 80 mg/kg), low dose treatment (LDT, 4 mg/kg supplement), and high dose treatment (HDT; 8 mg/kg supplement). Data represent mean ± standard deviations. and are values statistically different as indicated with and , respectively. (e) Effect of CellGevity dietary supplement on CYP2D6 activity in rat liver microsomes. Negative control (NC; distilled water), positive control (PC; phenobarbitone 80 mg/kg), low dose treatment (LDT, 4 mg/kg supplement), and high dose treatment (HDT; 8 mg/kg supplement). Data represent mean ± standard deviations. and are values statistically different as indicated with and , respectively. (f) Effect of CellGevity dietary supplement on CYP2C9 in rat liver microsome. Negative control (NC; distilled water), positive control (PC; phenobarbitone 80 mg/kg), low dose treatment (LDT, 4 mg/kg supplement), and high dose treatment (HDT; 8 mg/kg supplement). Charts represent mean ± standard deviations. are values statistically different as indicated with .

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